Accession Number : ADA457731


Title :   Neurotoxicity From Chronic Exposure to Depleted Uranium


Descriptive Note : Final rept. 1 Apr 2002-31 Mar 2006


Corporate Author : ILLINOIS UNIV AT CHICAGO


Personal Author(s) : Lasley, Stephen M.


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a457731.pdf


Report Date : APR 2006


Pagination or Media Count : 19


Abstract : This project is designed to test the hypothesis that chronic exposure to depleted uranium (DU) impairs neuronal processes underlying cognitive function via alterations induced at hippocampal glutamatergic synapses. Evidence has been uncovered that suggests a direct effect of uranium to diminish stimulated hippocampal glutamate release which may account for the reported decrease in neuronal excitability (3). However other findings indicate that long-term DU exposure may also inhibit glial glutamate and GABA uptake and up-regulate NMDA receptors possibly predisposing the individual to excitotoxicity and neurodegenerative disease. The establishment of the DU chronic exposure protocol as a shrapnel wound model based on blood and brain levels of the metal and altered rates of growth is also notable. These measures provide benchmark values for future studies and for correlation of results from this project to those obtained in other laboratories. Given the similarity of the effects of uranium on transmitter release to those of other multivalent metals (e.g. methylmercury lead) and the fact that exposure in military scenarios is continuing it is clear that additional studies are warranted on uranium's actions, particularly those related to developmental neurotoxicity.


Descriptors :   *EXPOSURE(GENERAL) , *IN VIVO ANALYSIS , *RECEPTOR SITES(PHYSIOLOGY) , *DEPLETED URANIUM , *HIPPOCAMPUS , *NEUROTOXINS , GLUTAMIC ACID , GROWTH(GENERAL) , NERVE CELLS


Subject Categories : ANATOMY AND PHYSIOLOGY
      TOXICOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE