Accession Number : ADA457493


Title :   The Pathogenesis and Therapy of Combined Radiation Injury


Descriptive Note : Technical rept.


Corporate Author : ITT INDUSTRIES INC ALEXANDRIA VA ADVANCED ENGINEERING AND SCIENCES DIV


Personal Author(s) : Boudagov, R. S. ; Oulianova, L. P. ; Tsyb, A. F.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA457493


Report Date : OCT 2006


Pagination or Media Count : 40


Abstract : Cytokine production by different kinds of macrophages, and serum IL-1Beta, TNF-alpha, IL-6, IL-3, and GM-CSF levels, were evaluated in a murine model of combined injury (whole body irradiation + thermal burn). The results were compared with systemic cytokine responses to radiation or burn alone. The obtained data suggest that increased IL-6 levels may play an important role in the pathogenesis of combined injury. Single injection of extract from Serratia marcescens (Imuvert) or synthetic trehalose dicorynomy-colate improved hematological status, enhanced the serum IL-6 levels, but did not promote survival in mice. On the other hand, heat-killed Lactobacillus acidophilus demonstrated a weak effect on cytokine response, did not improve severe hematological disorders, but none the less increased 30 days survival in mice up to 100%, versus 50% in the untreated group.


Descriptors :   *RESPONSE(BIOLOGY), *PATHOGENESIS, *CYTOKINES, *RADIATION INJURIES, MACROPHAGES, HEMATOLOGY, WHOLE BODY IRRADIATION, SERRATIA MARCESCENS


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE