Accession Number : ADA457493
Title : The Pathogenesis and Therapy of Combined Radiation Injury
Descriptive Note : Technical rept.
Corporate Author : ITT INDUSTRIES INC ALEXANDRIA VA ADVANCED ENGINEERING AND SCIENCES DIV
Personal Author(s) : Boudagov, R. S. ; Oulianova, L. P. ; Tsyb, A. F.
Report Date : OCT 2006
Pagination or Media Count : 40
Abstract : Cytokine production by different kinds of macrophages, and serum IL-1Beta, TNF-alpha, IL-6, IL-3, and GM-CSF levels, were evaluated in a murine model of combined injury (whole body irradiation + thermal burn). The results were compared with systemic cytokine responses to radiation or burn alone. The obtained data suggest that increased IL-6 levels may play an important role in the pathogenesis of combined injury. Single injection of extract from Serratia marcescens (Imuvert) or synthetic trehalose dicorynomy-colate improved hematological status, enhanced the serum IL-6 levels, but did not promote survival in mice. On the other hand, heat-killed Lactobacillus acidophilus demonstrated a weak effect on cytokine response, did not improve severe hematological disorders, but none the less increased 30 days survival in mice up to 100%, versus 50% in the untreated group.
Descriptors : *RESPONSE(BIOLOGY) , *PATHOGENESIS , *CYTOKINES , *RADIATION INJURIES , MACROPHAGES , HEMATOLOGY , WHOLE BODY IRRADIATION , SERRATIA MARCESCENS
Subject Categories : MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE