Accession Number : ADA455778


Title :   Cellular Retinoic Acid Binding Protein and Breast Cancer


Descriptive Note : Annual summary rept. 14 Apr 2003-13 Apr 2006


Corporate Author : CORNELL UNIV ITHACA NY


Personal Author(s) : Donato, Leslie J.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA455778


Report Date : MAY 2006


Pagination or Media Count : 24


Abstract : In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand.


Descriptors :   *BREAST CANCER , *RETINOIC ACIDS , CELLS(BIOLOGY) , METABOLITES , TRANSCRIPTION(GENETICS) , APOPTOSIS , RADIUM , MAMMARY GLANDS , VITAMIN A


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE