Accession Number : ADA449539


Title :   DNA Microarray Analysis of Human Monocytes Early Response Genes upon Infection with Rickettsia rickettsii


Descriptive Note : Briefing charts


Corporate Author : NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD


Personal Author(s) : Chao, Chien-Chung


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA449539


Report Date : 15 NOV 2004


Pagination or Media Count : 19


Abstract : Rickettsia are arthropod-borne bacteria which have caused diseases that have had a military impact by sweeping through troops and incapacitating them, such as the so called Trench Fevers of World War I and II. Rickettsia rickettsii is commonly known as Rocky Mountain spotted fever, the most commonly fatal tick-borne disease in the United States. Differentiating rickettsial diseases from other acute tropical febrile illnesses can be difficult because of the similarities in signs and symptoms. This briefing explores the hypothesis that as infection of human monocytes with R. rickettsii causes a specific mRNA expression pattern, this pattern could be used to distinguish different types of infection and to identify novel genes involved in host response.


Descriptors :   *MONOCYTES , *RICKETTSIA , SYMPOSIA , DIAGNOSIS(MEDICINE) , GENES


Subject Categories : GENETIC ENGINEERING AND MOLECULAR BIOLOGY
      MEDICINE AND MEDICAL RESEARCH
      MICROBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE