Accession Number : ADA447708


Title :   Programme DNA Lattices: Design, Synthesis and Applications


Descriptive Note : Final technical rept. Sep 2001-Sep 2005


Corporate Author : DUKE UNIV DURHAM NC OFFICE OF RESEARCH SUPPORT


Personal Author(s) : Reif, John


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a447708.pdf


Report Date : Feb 2006


Pagination or Media Count : 74


Abstract : Programmable methods for construction of complex structured objects on the 10-100 nm scale. Self-assembled DNA nanostructures provide a methodology for bottom-up nanoscale construction of highly patterned systems, utilizing macromolecular DNA tiles composed of branched DNA, self-assembled into periodic and aperiodic lattices. This methodology is programmable by choice of the set of DNA tiles, and can form any computable 2D or 3D pattern. Work was done by three leading research groups in DNA lattices: Duke (Reif); NYU (Seeman); and Caltech (Winfree). These experimental techniques were extended to assemble DNA lattices with complex 2D patterning and periodic 3D DNA lattices for the first time. This provides a flexible nanostructure construction methodology. By selectively attaching various other types of molecules to the tiles of the lattices, these lattices can be used as superstructures for placement of nanocomponents composed of a wide variety of other materials. The ability to form programmable, patterned nanostructured DNA lattices, as demonstrated for the first time in this project, opens many key opportunities for applied research in nanoscale science and engineering, including their application as scaffolds and superstructures for aligning proteins for crystallography studies, molecular electronics and nanorobotics.


Descriptors :   *DEOXYRIBONUCLEIC ACIDS , *NANOSTRUCTURES , *SELF ASSEMBLED MONOLAYERS , METHODOLOGY , ROBOTICS , CONDUCTIVITY , PATTERNS , SOFTWARE TOOLS , SUPERSTRUCTURES , THREE DIMENSIONAL , MATERIALS , PROTEINS


Subject Categories : Genetic Engineering and Molecular Biology
      Electrical and Electronic Equipment


Distribution Statement : APPROVED FOR PUBLIC RELEASE