Accession Number : ADA443698


Title :   Do Perturbed Epithelial-Mesenchymal Interactions Drive Early Stages of Carcinogenesis?


Descriptive Note : Annual rept. 1 Apr 2004-31 Mar 2005


Corporate Author : TUFTS UNIV BOSTON MA


Personal Author(s) : Sonnenschein, Carlos


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA443698


Report Date : APR 2005


Pagination or Media Count : 52


Abstract : This research project had three specific aims. The first was to determine which tissue in the rat mammary gland was the target of the chemical carcinogen N-nitrosomethylurea. This aim was fulfilled. The second aim included screening and counting lesions and performing morphometric data analysis of whole mounts (branching pattern, relative abundance of the different ductal and alveolar structures). These studies aimed at identifying the changes occurring between the time of exposure and the appearance of neoplasias. This aim was also fulfilled. Finally, as described for Aim #3, during years two and three we explored the specific roles of hyaluronan and emmprin, two molecules that are enriched in tumors and involved in tumorstromal cell interactions as mediators of neoplastic initiation and progression.


Descriptors :   *EPITHELIUM , *ONCOGENESIS , NEOPLASMS , MUTATIONS , CELLS(BIOLOGY) , LESIONS , MAMMARY GLANDS


Subject Categories : ANATOMY AND PHYSIOLOGY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE