Accession Number : ADA443045


Title :   Intermittent Ultrasound Imaging of Prostate Cancer


Descriptive Note : Final rept. 1 Aug 2001-31 Jul 2005


Corporate Author : JEFFERSON MEDICAL COLL PHILADELPHIA PA


Personal Author(s) : Halpern, Ethan J.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA443045


Report Date : AUG 2005


Pagination or Media Count : 39


Abstract : This study proposed to evaluate contrast-enhanced ultrasound imaging with a microbubble contrast agent in 300 subjects in order to improve the detection of prostate cancer. Between October 2001 and January 2004 a total of 301 subjects were enrolled. Laboratory blood tests (PSA) and ultrasound evaluations were completed on all 301 subjects (including the primary ultrasound interpretation worksheet). Independent blinded readers have reviewed imaging on all subjects. Pathological review for the presence and grade of cancer has been completed for all subjects. CD31 staining for micro-vessel density has been performed on the first 40 subjects. All available data has been entered into a computer database using an Excel spreadsheet. Analysis of the prostate cancer detection data from all 301 subjects was incorporated into a manuscript that has been accepted for publication in the journal "Cancer". The final analysis of microvessel density has been accepted for presentation at the annual meeting of the Radiological Society of North America (Dec 2005). Copies of the manuscript and the abstract are appended to this report.


Descriptors :   *PATHOLOGY , *RADIOLOGY , *BLOOD ANALYSIS , *ULTRASONIC RADIATION , *PROSTATE CANCER , TEST AND EVALUATION , DATA BASES , CONTRAST , SPREADSHEET SOFTWARE , LABORATORY TESTS , DETECTION , NORTH AMERICA , SOCIETIES , COMPUTERS , IMAGES , BUBBLES


Subject Categories : ANATOMY AND PHYSIOLOGY
      MEDICINE AND MEDICAL RESEARCH
      MEDICAL FACILITIES, EQUIPMENT AND SUPPLIES


Distribution Statement : APPROVED FOR PUBLIC RELEASE