Accession Number : ADA442686


Title :   The Establishment of an Inflammatory Breast Cancer Registry and Biospecimen Repository


Descriptive Note : Final rept. 1 Aug 2001-31 Jul 2005


Corporate Author : GEORGE WASHINGTON UNIV WASHINGTON DC


Personal Author(s) : Levine, Paul H.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA442686


Report Date : AUG 2005


Pagination or Media Count : 426


Abstract : From Sept. 10, 2002 to July 31, 2005, 173 patients contacted the Inflammatory Breast Cancer (IBC) Registry. From that total, 163 returned Informed Consent forms, 151 were interviewed by the Principal Investigator, and 150 completed the IBC Questionnaire. Tissue blocks and frozen surgical specimens were obtained from 110 and 10 patients, respectively. Biospecimens were forwarded to 5 laboratories, with 3 reporting results thus far. Data on the first 50 patients were presented at the San Antonio Breast Cancer Conference in Dec. 2003 and initial evaluation of the questionnaire data was presented at the same conference in Dec. 2004. The clinical data include the observation that approximately 1/4 of IBC patients were initially diagnosed with mastitis and treated with up to 5 months of antibiotics before the diagnosis of cancer was made. Less than 25% of patients have a discrete mass identified on initial mammography. Laboratory data thus far (45 patients) indicate that the tumors from IBC patients express significant amounts of BP-1, a homeobox gene associated with breast cancer aggressiveness. Also, tumors from a higher percentage of IBC than non-IBC breast cancer patients express gene sequences resembling mouse mammary tumor virus. A pilot study found overexpression of C12 proteins, which play an important role in a cancer's ability to invade their local environment, which was far more marked than in non-inflammatory infiltrating ductal breast cancers.


Descriptors :   *BREAST CANCER , TISSUES(BIOLOGY) , EXPERIMENTAL DATA , MASS , CLINICAL MEDICINE , GENES , PILOT STUDIES , MICE , MAMMOGRAPHY , VIRUSES , INFLAMMATION , ANTIBIOTICS , MAMMARY GLANDS , BIOPSY , GROWTH(PHYSIOLOGY) , HISTOLOGICAL TECHNIQUES


Subject Categories : ANATOMY AND PHYSIOLOGY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE