Accession Number : ADA442246


Title :   Intensity Modulated Radiation Treatment of Prostate Cancer Guided by High Field MR Spectroscopic Imaging


Descriptive Note : Annual rept. 1 May 2004-30 Apr 2005


Corporate Author : LELAND STANFORD JUNIOR UNIV STANFORD CA


Personal Author(s) : Xing, Lei


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA442246


Report Date : MAY 2005


Pagination or Media Count : 186


Abstract : With the development of computer controlled multileaf collimators, IMRT now provides unprecedented means for us to deliver 3D-dose distributions with sub-centimeter resolution. Simultaneously, MRSI is capable of noninvasively providing critically needed 3D metabolic and physiological information. Together with anatomical CT/MRI, functional imaging affords valuable 4D data (3D structural plus 1D metabolic). A timely issue is how to integrate the metabolic/functional data into IMRT planning to improve clinical prostate cancer management. Toward establishing biologically conformal radiation therapy for prostate treatment, we have carried out a series of studies and developments and have successfully accomplished a number of important milestones of the proposed project. These include refined the endorectal coil-based 3T prostate MRSI technique for prostate imaging; developed a narrow band technique for deformable image registration of endorectal coil-based MRI/MRSI and treatment planning CT images; developed a novel inverse planning system that is capable of incorporating prior clinical knowledge; established an adaptive technique for producing optimal voxel-dependent penalty scheme for prostate IMRT planning; proposed a biological model-based BCRT inverse planning technique and laid technique foundation for BCRT. It is expected these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of MRSI-guided prostate treatment.


Descriptors :   *RESONANCE RADIATION , *COMPUTERIZED TOMOGRAPHY , *PROSTATE CANCER , *MAGNETIC RESONANCE IMAGING , ALGORITHMS , VALIDATION , ONE DIMENSIONAL , PROSTATE GLAND , COLLIMATORS , THREE DIMENSIONAL , IMAGES , ADAPTIVE SYSTEMS , INVERSION


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      THEORETICAL MATHEMATICS


Distribution Statement : APPROVED FOR PUBLIC RELEASE