Accession Number : ADA439215


Title :   An MR Contrast Agent for Intra-Prostatic Imaging of Prostatic Cancer


Descriptive Note : Annual rept.


Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON


Personal Author(s) : Josephson, Lee


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA439215


Report Date : JAN 2005


Pagination or Media Count : 8


Abstract : An MR contrast agent targeted to the GRP receptor will be a novel pharmaceutical capable of non-invasively, and at high spatial resolution, characterizing healthy and patholological regions within the prostate. The goal of the research is to develop a magnetic nanoparticle MR contrast targeted to the gastrin releasing peptide receptor (GRP receptor) that will be used to image the intra-prostatic distribution of this key molecular marker. Because of technical problems in imaging the GRP receptor in animal models of prostate cancer, we have been imaging the expression of this receptor in the normal mouse pancreas Our long term goal is to use this animal model to refine our understanding of the interaction of magnetic nanoparticles with this receptor and return to the animal prostate cancer models.


Descriptors :   *MAGNETIC PROPERTIES , *MAGNETIC RESONANCE IMAGING , *PROSTATE CANCER , CONTRAST , SKILLS , PEPTIDES , ENZYMES , DISPLACEMENT , PARTICLES , RELEASE , IMMUNOASSAY , SENSE ORGANS , GASTRIN.


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      NUCLEAR PHYSICS & ELEMENTARY PARTICLE PHYSICS


Distribution Statement : APPROVED FOR PUBLIC RELEASE