Accession Number : ADA429279
Title : Replacing the Nucleobases in DNA with Designer Molecules
Descriptive Note : Journal article
Corporate Author : STANFORD UNIV CA DEPT OF CHEMISTRY
Personal Author(s) : Kool, Eric T.
Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA429279
Report Date : 26 JUL 2003
Pagination or Media Count : 9
Abstract : DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.
Descriptors : *DEOXYRIBONUCLEIC ACIDS , FLUORESCENCE , LIGANDS , RIBONUCLEIC ACIDS , GENETICS , HELIXES.
Subject Categories : BIOCHEMISRTY
Distribution Statement : APPROVED FOR PUBLIC RELEASE