Accession Number : ADA429279


Title :   Replacing the Nucleobases in DNA with Designer Molecules


Descriptive Note : Journal article


Corporate Author : STANFORD UNIV CA DEPT OF CHEMISTRY


Personal Author(s) : Kool, Eric T.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA429279


Report Date : 26 JUL 2003


Pagination or Media Count : 9


Abstract : DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.


Descriptors :   *DEOXYRIBONUCLEIC ACIDS , FLUORESCENCE , LIGANDS , RIBONUCLEIC ACIDS , GENETICS , HELIXES.


Subject Categories : BIOCHEMISRTY
      ORGANIC CHEMISTRY
      OPTICS


Distribution Statement : APPROVED FOR PUBLIC RELEASE