Accession Number : ADA427170


Title :   Anti-Angiogenic Gene Therapy for Prostate Cancer


Descriptive Note : Annual rept.


Corporate Author : ALABAMA UNIV IN BIRMINGHAM


Personal Author(s) : Ponnazhagan, Selvarangan


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a427170.pdf


Report Date : Apr 2004


Pagination or Media Count : 61


Abstract : One of the major implications of prostate cancer progression is bone metastasis. Primary therapies for neoplastic prostate disease have been prostectomy followed by chemotherapy and radiation therapy. Although these forms of palliative therapies have been successful in early detected prostate cancers, a problem in majority of the treated cases is the growth of radiation/chemotherapy resistant tumor cells, which become refractory to treatment and exhibit an aggressive growth and metastatic profile. Thus, novel therapies that will control the process of recurrence and metastasis will have a profound clinical implication in the management of prostate cancer patients who undergo primary therapies.


Descriptors :   *PROSTATE CANCER , *ANGIOGENESIS , DISEASES , NEOPLASMS , PROFILES , THERAPY , PATIENTS , BLOOD VESSELS , GENE THERAPY , CHEMOTHERAPY , BONES , GROWTH(PHYSIOLOGY) , PROSTATE GLAND , METASTASIS , RADIOTHERAPY


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE