Accession Number : ADA424947


Title :   Water Powered Bioassay System


Descriptive Note : Final technical rept. Sep 2000-Dec 2003


Corporate Author : CALIFORNIA UNIV BERKELEY DEPT OF MECHANICAL ENGINEERING


Personal Author(s) : Lin, Liwei


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a424947.pdf


Report Date : Jun 2004


Pagination or Media Count : 108


Abstract : This project addresses critical technologies, including the acquisition, metering, buffering, delivery and assay for the processing of bio-fluids that enable the complete integration of microfluidic chips into systems. An all-plastic micromachined water-powered pump was first developed that provided a constant rate fluidic delivery of 0.2 1/hr without requiring electrical power. A low-leakage, hole-in-the-wall micro valve was demonstrated that provided fluidic resistance 255 times higher in the closed state than in the open state. A micro-accumulator was designed, fabricated, and demonstrated that repeatedly stored and delivered fluidic pressure and, with a combination of pumps and valves, formed the basic micro fluidic processing unit. The addition of integrated micro dialysis needles and a bioassay system completed the system by providing the capability of extracting interstitial liquid directly from tissue and making a real- time diagnosis. A water-activated micro power battery was constructed and operated that delivered 0.6 V of power, and was demonstrated by driving a 10 kohm resistor for more than one hour. These micro-fluidic components and system integration technologies are leading the way in developing a microsystem to process microfluidics on a single chip.


Descriptors :   *OSMOTIC PRESSURE , *PUMPS , *FLUIDICS , INTEGRATED SYSTEMS , CHIPS(ELECTRONICS) , ELECTRIC POWER , BIOASSAY , DIALYSIS


Subject Categories : Fluidics and Fluerics
      Pumps, Filters, Pipes, Tubing, Fittings & Vlvs


Distribution Statement : APPROVED FOR PUBLIC RELEASE