Accession Number : ADA418353


Title :   Folate and Breast Cancer: Role of Intake, Blood Levels and Metabolic Gene Polymorphisms


Descriptive Note : Annual summary rept. 1 Jun 2002-31 May 2003


Corporate Author : VANDERBILT UNIV MEDICAL CENTER NASHVILLE TN


Personal Author(s) : Shrubsole, Martha J. ; Zheng, Wei


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA418353


Report Date : JUN 2003


Pagination or Media Count : 30


Abstract : The purpose of this application is training in nutritional and molecular epidemiology with the eventual goal of establishing an independent investigator. The hypothesis major hypothesis of the project is that high folate intake is associated with a decreased breast cancer risk particularly among those with MTHFR, MTR, and MTRR polymorphisms. The specific aims of this postdoctoral training proposal are 1) further methodological training in the analysis of gene-gene and gene-environment interactions by studying folate intake and folate metabolic gene polymorphisms (MTHFR, MTR, MTRR) using data collected in a population-based breast cancer case-control study (approximately 3000 subjects), 2) training in the methodology of cohort studies through designing and implementing a newly proposed nested case-control study of breast cancer (350 pairs) to examine folate intake, plasma folate, and metabolic gene polymorphisms, 3) coursework in nutrition and cancer biology and 4)participation in the field work of a recently submitted breast cancer case-control study and 5) development of a grant proposal examining folate, global DNA methylation and uracil misincorporation in breast cancer risk.


Descriptors :   *PREVENTIVE MEDICINE, *FOLIC ACID, *BREAST CANCER, METABOLISM, GENES, NUTRITION, EPIDEMIOLOGY, POLYMORPHISM, METHYLATION.


Subject Categories : ANATOMY AND PHYSIOLOGY
      MEDICINE AND MEDICAL RESEARCH
      FOOD, FOOD SERVICE AND NUTRITION


Distribution Statement : APPROVED FOR PUBLIC RELEASE