Accession Number : ADA409881


Title :   Effect of Calcium-Activated Chloride Current Blockade on the Delayed Afterdepolarizations. Simulation Study


Corporate Author : UNIVERSIDAD POLITECNICA DE VALENCIA (SPAIN) LABORATORIO INTEGRADO DE BIOINGENIERIA


Personal Author(s) : Gomis-Tena, J. ; Saiz, J.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA409881


Report Date : 25 OCT 2001


Pagination or Media Count : 5


Abstract : High intracellular calcium conditions cause a calcium-activated transient inward current (I to the ti) that can provoke oscillations in membrane potential called delayed afterdepolarizations (DAD)). The current I to the ti comprises of the sodium-calcium exchange current (I to the CI-Ca) and the calcium activated chloride current (1ci-ca) Lindblad, Murphey, Clark and Ciles developed a mathematical model (LMCC model) of the rabbit atrial AP, In this study, a modified AP LMCC model that includes I to the ci-ca is used to evaluate the contribution of I to the ci-ca to develope DADs, Our results suggest that although I to the NaCa is the main component of I to the ti ( 65% ), I to the ci-ca may play a significant role in DAD generation, Even more, the I to the ci-ca blockade could inhibit the DAD propagation and trigger activity associated to high Ca2+ condition, in atrial tissue,


Descriptors :   *CALCIUM , *CHLORIDES , *CELLS(BIOLOGY) , SIMULATION , ACTIVATION , MEMBRANES , SPAIN , OSCILLATION , RABBITS , TRIGGER CIRCUITS.


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE