Accession Number : ADA359058


Title :   Treatment of Experimental Acute Radiation Disease in Mice with Probiotics, Quinolones, and General Gnotobiological Isolation


Descriptive Note : Contract rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Korschunov, Valerji M. ; Efimov, Boris A. ; Smeyanov, Vladlmir V. ; Balnov, Nicholaj A. ; Pikina, Alla P.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA359058


Report Date : SEP 1998


Pagination or Media Count : 41


Abstract : The effect of ciprofloxacin, lomefloxacin, amikacin, and probiotics (Lactobacillus acidophilus 5/4, Bifidobacterium longum 44) on intestinal microflora, translocation, and mortality was studied in mice treated with 7.0 Gy radiation. Lactobacilli and bifidobacteria, selected by in vitro and in vivo methods, increased survival parameters of the mice. The effect of lactobacilli was higher under gnotobiological isolation. Lactobacilli suppressed the gram-negative enterics and decreased translocation of the strict anaerobes, but not streptococci. Lomefloxacin increased survival, reducing the intestinal counts and translocation of gram-negative enterics, but not streptococci. A lomefloxacin/lactobacilli combination showed effects similar to lomefloxacin alone.


Descriptors :   *RADIATION, *ENTERIC BACTERIA, *ANAEROBIC BACTERIA, *GRAM NEGATIVE BACTERIA, *IN VITRO ANALYSIS, *LACTOBACILLUS, MICE, IN VIVO ANALYSIS, INTESTINES, STREPTOCOCCUS, METHODOLOGY, ISOLATION, COUNTING METHODS, PARAMETERS, ANTIBIOTICS, TRANSLOCATION


Subject Categories : ANATOMY AND PHYSIOLOGY
      MEDICINE AND MEDICAL RESEARCH
      RADIOBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE