Accession Number : ADA284926


Title :   Synaptic Plasticity and Memory Formation


Descriptive Note : Annual rept. 1 Jun 1993-31 May 1994


Corporate Author : CALIFORNIA UNIV IRVINE CENTER FOR THE NEUROBIOLOGY OF LEARNING AND MEMORY


Personal Author(s) : Lynch, Gary


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA284926


Report Date : 31 MAY 1994


Pagination or Media Count : 5


Abstract : Work described in past progress reports led to the conclusion that the postsynaptic glutamate receptors which mediate fast, excitatory transmission in mammalian brain are the sites at which the changes responsible for LTP occur. Moreover, pharmacological and physiological experiments indicated that the nature of the change involved a modification of receptor channel kinetics. Modelling studies, incorporating this information into a biologically realistic simulation of the receptor, resulted in a specific hypothesis about which the channel opens and closes (see Progress Report, 1992-1993). During the past year, experimental work was carried out to test this hypothesis. This involved hippocampal slices in which fast, excitatory responses were isolated by pharmacologically blocking inhibitory conductances and post-synaptic spiking. The synaptic responses in those 'disinhibited' slices are simple reflections, modified by dendritic filtering, of AMPA receptor mediated currents.


Descriptors :   *MEMORY(PSYCHOLOGY) , *SYNAPSE , *NEUROPHYSIOLOGY , *NEUROBIOLOGY , TEST AND EVALUATION , SIMULATION , SITES , RESPONSE , PLASTIC PROPERTIES , KINETICS , FILTRATION , BLOOD BRAIN BARRIER , CHANNELS , BLOCKING , WORK , PHYSIOLOGICAL EFFECTS , REFLECTION , BRAIN , MODIFICATION


Subject Categories : PSYCHOLOGY
      BIOLOGY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE