Accession Number : ADA251871


Title :   New Therapeutic Modalities of Retinal Laser Injury.


Descriptive Note : Final rept. 1 Mar 89-1 Mar 92,


Corporate Author : ILLINOIS UNIV AT CHICAGO CIRCLE DEPT OF OPHTHALMOLOGY


Personal Author(s) : Lam, Tim T. ; Tso, Mark O.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA251871


Report Date : 31 MAR 1992


Pagination or Media Count : 77


Abstract : Efficacies of three different regimens of high dose of methylprednisolone (MP) treatment on laser-induced non-hemorrhage retinal injury and tissue plasminogen activator (t-PA) in sub-retinal hemorrhage laser injury were evaluated in a sub-human primate model and a rat model respectively. Clinical, histopathological, and morphometric criteria were employed for evaluating the efficacy of MP. High dose and prolonged treatment (4 days) was the most effective regimen while high dose for 8 hours showed limited effect in non-hemorrhagic retinal injury. Intravitreal t-PA showed no apparent beneficial effect in sub-retinal hemorrhage after laser injury. Hence, patients with laser retinal injury may benefit from high dose MP treatment for an appropriate period of time. Laser, Retina, Injury, Treatment, Corticosteroids, Methylprednisolone, tissue plasminogen activator, sub-retinal hemorrhage, RA 3.


Descriptors :   *RETINA , *SURGERY , MODELS , RATS , HUMANS , BENEFITS , ENZYME PRECURSORS , HEMORRHAGE , PATIENTS , PRIMATES , LASERS , TIME


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE