Accession Number : ADA224055


Title :   Social Behavior, Prolactin and the Immune Response


Descriptive Note : Final rept. 30 Oct 1987-29 Oct 1988,


Corporate Author : GEORGIA UNIV ATHENS DEPT OF PSYCHOLOGY


Personal Author(s) : Bunnell, B N ; Iturrian, W B


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a224055.pdf


Report Date : 01 Apr 1989


Pagination or Media Count : 97


Abstract : The goal of the project was to develop a nonhuman primate model for studying the effects of social stress on immune system function. In this pilot project, stress was defined as activation of the pituitary-adrenal axis. Particular interest was in seeking correlations between social variables, immune function indicants, and serum levels of prolactin as a presumptive immunofacilitory hormone. Mitogen responses to a physical stressor (footshock) were used for assay development and as a base for examining social stress effects. Social stress was manipulated by changing the composition of the social stress effects. Social stress was manipulated by changing the composition of the social groups. Complex effects relating mitogen responses to social variables were found, with social manipulations producing suppression of PBL proliferation followed by a rebound in some situations; facilitation in others, depending upon the situation and the type of individual involved. Evidence indicated that increased social status associated with increased PBL response. Report includes descriptions of comparisons of thymidine and colorimetric assay techniques for responses to mitogen stimulation. (jes)


Descriptors :   *SOCIAL PSYCHOLOGY , CORRELATION , PILOT STUDIES , RESPONSE(BIOLOGY) , BLOOD SERUM , PROLACTIN , HOMING , ASSAYING , COLORIMETRY , ACTIVATION , IMMUNITY


Subject Categories : Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE