Accession Number : ADA220725


Title :   Therapeutic Approaches to the Treatment of Botulism


Descriptive Note : Final rept. 1 Sep 1985-5 Jul 1989


Corporate Author : JEFFERSON MEDICAL COLL PHILADELPHIA PA


Personal Author(s) : Simpson, Lance L.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA220725


Report Date : 01 OCT 1989


Pagination or Media Count : 40


Abstract : Research has been conducted in four areas that pertain to the development of antagonists of botulinum neurotoxin, as follows: 1) Studies on monoclonal antibodies indicate that they are useful research tools, but they appear to have little therapeutic potential. 2) Research on aminopyridines and their analogues shows that they possess anti-botulinum activity, but only of a narrow utility. 3) Experiments with dendrotoxin have resulted in the provocative finding that this agent does not antagonize any clostridial toxin, nor does it reverse the effects of low calcium or high magnesium. 4) Initial studies on rubidium flux indicate that this may represent a rational approach for finding clostridial toxin antagonists. Keywords: Botulinum neurotoxin; Neuromuscular blockade; Experimental therapeutics.


Descriptors :   *THERAPY , *BOTULISM , MAGNESIUM , CALCIUM , FLUX(RATE) , MONOCLONAL ANTIBODIES , BACTERIAL TOXINS , CLOSTRIDIUM BOTULINUM , RUBIDIUM , NEUROMUSCULAR TRANSMISSION , NERVE BLOCKING.


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      TOXICOLOGY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE