Accession Number : ADA214522


Title :   Workshop on Cytokines and Parasites


Descriptive Note : Final rept. 30 Sep 1987-1 Mar 1988


Corporate Author : WISCONSIN UNIV-MADISON DEPT OF MICROBIOLOGY


Personal Author(s) : Byrne, Gerald ; Nacy, Carol A.


Report Date : 01 MAR 1988


Pagination or Media Count : 10


Abstract : Immunoregulatory cytokines are the hormonal factors that direct and fine-tune effector reactions of immune responses. Spectacular advances in technologies for isolation and purification of these cytokines, in particular the development of monoclonal antibody and molecular biology methodologies, have enabled scientists to examine the regulatory roles of single cytokines, as well as analyze the interrelationships and synergy between different cytokines. The application of this information to immunotherapy of neoplastic diseases has proceeded beyond the animal model stage, and several different cytokines are presently in clinical trials (Interleukin-2, Granulocyte-macrophage Colony Stimulating Factors, Interferon alpha). The one day meeting on Parasites and Cytokines, held in conjunction with the International Congress of the Reticuloendothelial Society focused attention of the immunological community on the unique problems associated with parasitic diseases, and explored the options of immunotherapy in infectious diseases for which there are presently no vaccines, or for which direct stimulation of the host's immune system during infection might be detrimental to survival. Keywords: RA I; BW Defense; Cytokines; Immunomodulation; Macrophages immunotherapy; Infectious diseases; Parasites.


Descriptors :   *PARASITES , *PARASITIC DISEASES , HORMONES , STIMULATION(GENERAL) , COMMUNITIES , MODELS , ISOLATION , DISEASES , NEOPLASMS , SURVIVAL(GENERAL) , PURIFICATION , ANTIBODIES , MOLECULAR BIOLOGY , CLONES , ANIMALS , INTERNATIONAL , CELL DIVISION , RESPONSE(BIOLOGY) , IMMUNOLOGY , INTERFERON , INFECTIOUS DISEASES , IMMUNITY , GRANULOCYTES , COLONIES(BIOLOGY) , VACCINES , RETICULOENDOTHELIAL SYSTEM , PHAGOCYTES , METHODOLOGY , CONGRESS


Subject Categories : BIOCHEMISRTY
      BIOLOGY
      CHEMICAL, BIOLOGICAL AND RADIOLOGICAL WARFARE


Distribution Statement : APPROVED FOR PUBLIC RELEASE