Accession Number : ADA213886


Title :   Carboxyalkylated Hemoglobin as a Potential Blood Substitute


Descriptive Note : Annual rept. 1 Sep 1988-31 Aug 1989


Corporate Author : ROCKEFELLER UNIV NEW YORK


Personal Author(s) : Manning, james M.


Report Date : 20 SEP 1989


Pagination or Media Count : 20


Abstract : Our emphasis has been on two major objectives. We have determined the properties of the carboxymethyl derivative of hemoglobin to determine whether they are consistent with its possible future use as a blood substitute. We have evidence that this derivative is analogous to that formed in the reaction of hemoglobin with CO2. This natural product results in a very low oxygen affinity for hemoglobin, which is a very desirable property for a blood substitute. The second major objective of our research has been to cross-link this hemoglobin derivative in a manner that will maintain the essential functional properties of hemoglobin. (kt)


Descriptors :   *ALKYLATION , *BLOOD SUBSTITUTES , *HEMOGLOBIN


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE