Accession Number : ADA205812


Title :   Radiation-Induced Impairment of Neuronal Excitability


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Pellmar, T C ; Tolliver, J M ; Neel, K L


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a205812.pdf


Report Date : Jan 1988


Pagination or Media Count : 11


Abstract : Radiation causes a decrease in the synaptically evoked activity of CA1 hippocampal pyramidal cells. This effect is dose and dose-rate dependent. Hydrogen peroxide, which produces hydroxyl free radicals when combined with FE + 2, produces similar damage. In contrast, the radioprotectant, dithiothreitol, increases the excitability of hippocampal neurons. These studies indicate that radiation can directly affect the function of central neurons. Keywords: X rays, Radiation effects, Nerve transmission, Reprints, Stimulation physiology.


Descriptors :   *NERVE TRANSMISSION , *RADIATION EFFECTS , X RAYS , NERVE CELLS , FREE RADICALS , RADIOPROTECTIVE AGENTS , HYDROXYL RADICALS , HIPPOCAMPUS , HYDROGEN PEROXIDE , STIMULATION(PHYSIOLOGY) , REPRINTS , SYNAPSE


Subject Categories : Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE