Accession Number : ADA199085


Title :   Structure and Design of Multipotent Peptide Microbicides


Descriptive Note : Annual rept. 1 Aug 1987-1 Aug 1988


Corporate Author : CALIFORNIA UNIV LOS ANGELES SCHOOL OF MEDICINE


Personal Author(s) : Selsted, Michael E.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA199085


Report Date : 01 AUG 1988


Pagination or Media Count : 8


Abstract : The goal of this project is to design novel peptide antibiotics using a naturally occurring family of peptides, known as defensins, as models. Defensins are homologous peptides, 29-34 residues in length, which are major constituents of the cytoplasmic granules of polymorphonuclear leukocytes. The structural hallmark of the defensin peptide family is a conserved infrastructure comprised of 1 arginine, 1 glycine, and 6 disulfide-linked cysteine residues. Although the peptides are similar in their overall fold, they possess diverse antimicrobial spectra and potencies. By correlating specific biocidal activities with unique structural features, we seek to design custom peptide antimicrobials based on structure-function principles derived from these studies. Insight into the molecule details of the peptide-target cell interactions may contribute to the general understanding of protein-membrane recognition processes. Keywords: Neutrophils, Synthesis(Chemistry).


Descriptors :   *ANTIBIOTICS , PEPTIDES , CYTOPLASM , CYSTEINE , POTENCY , MEMBRANES(BIOLOGY) , GLYCINE , POLYMORPHONUCLEAR LEUKOCYTES , GRANULES , POLYMORPHONUCLEAR NEUTROPHILS , ANTIMICROBIAL AGENTS


Subject Categories : GENETIC ENGINEERING AND MOLECULAR BIOLOGY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE