Accession Number : ADA184922


Title :   Testing Experimental Compounds against Leishmaniansis in Laboratory Animal Model Systems


Descriptive Note : Annual summary rept. 15 Dec 1983-1 Nov 1984


Corporate Author : CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK


Personal Author(s) : Keithly, Jan S


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a184922.pdf


Report Date : Sep 1984


Pagination or Media Count : 64


Abstract : Pentostam Dose Responses for L. donovani, L. m. mexicana, and L. b. guyanensis have been determined in BALB/c mice using amastigotes (A), primary culture promastigotes (PCP), and subcultured promastigotes (SP). In each test system, PCP are more resistant to treatment than are A or SP. This is biologically significant, since PCP are equivalent to the ineffective stage from sandflies. The data also show that Pentostam causes improvement and parasitological cures in WRAIR primary (hamster), secondary (BALB/c), and tertiary (owl monkey) test systems at doses and regimes equivalent to those used to treat humans. The validity of each of these models in drug screening to predict the outcome in human infections is established. Seven of 10 WRAIR 1984 compounds suppress L. donovani 79 to 94% at the MTD MTD/2, and MTD/4. It is highly probable they will be competitive with Pentostam.


Descriptors :   *CHEMOTHERAPEUTIC AGENTS , *CHEMOTHERAPY , *LEISHMANIASIS , DOSAGE , MICE , PHYSIOLOGICAL EFFECTS


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE