Accession Number : ADA181931
Title : Effect of Temperature on the Vector Efficiency of Aedes aegypti for Dengue 2 Virus
Descriptive Note : Journal articlce.
Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Personal Author(s) : Watts, Douglas M. ; Burke, Donald S. ; Harrison, Bruce A. ; Whitmire, Richard E. ; Nisalak, Ananda
Report Date : 26 JUN 1986
Pagination or Media Count : 10
Abstract : The effect of temperature on the ability of Aedes Aegypti to transmit dengue (DEN) 2 virus to rhesus monkeys was assessed as a possible explanation for the seasonal variation in the incidence of dengue hemorrhagic fever in Bangkok, Thailand. In two laboratory experiments, a Bangkok strain of Ae. aegypti was allowed for feed upon viremic monkeys infected with DEN-2 virus. Blood-engorged mosquitoes were separated into two groups and retained at constant temperatures. Virus infection and transmission rates were determined for Ae. aegypti at intervals ranging from 4 to 7 days during a 25-day incubation period. Results of the first experiment for mosquitoes infected with a low dose of DEN-2 virus and maintained at 20, 24, 26, and 30C, indicated that the infection rate ranged from 25% to 75% depending on the incubation period. However, DEN-2 virus was transmitted to monkeys only by Ae. aegypti retained at 30C for 25 days. In the second experiment, the infection rate for Ae. aegypti that ingested a high viral dose, and incubated at 26, 30, 32, and 35C ranged from 67% to 95%. DEN-2 virus was transmitted to monkeys only by mosquitoes maintained at > or = 30C. The extrinsic incubation period was 12 days for mosquitoes at 30C, and was reduced to 7 days for mosquitoes at 32C and 35C. These results imply that temperature-induced variations in the vector efficiency of Ae. aegypti may be a significant determinant in the annual cyclic pattern of dengue hemorrhagic fever epidemics in Bangkok.
Descriptors : *TEMPERATURE , *INFECTIOUS DISEASE TRANSMISSION , *DISEASE VECTORS , *DENGUE , *VECTOR ANALYSIS , *AEDES , TRANSMITTANCE , REPRINTS , DOSAGE , CULICIDAE , PATTERNS , INCUBATION , INFECTIOUS DISEASES , HEMORRHAGIC FEVERS , VIRUS DISEASES , VIRUSES , EPIDEMIOLOGY , THAILAND , RHESUS MONKEYS , CYCLES , EFFICIENCY , RATES , LABORATORY TESTS , MONKEYS , SEASONAL VARIATIONS
Subject Categories : MEDICINE AND MEDICAL RESEARCH
Distribution Statement : APPROVED FOR PUBLIC RELEASE