Accession Number : ADA177153


Title :   Pathogenesis of Cell Injury by Rickettsia conorii


Descriptive Note : Annual rept. 11 Apr 1985-6 Aug 1986; Final rept. 11 Apr 1983-6 Aug 1986


Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL


Personal Author(s) : Walker, David H.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA177153


Report Date : 26 NOV 1986


Pagination or Media Count : 59


Abstract : This work was undertaken to determine the pathogenic mechanism by which Rickettsia conorii causes disease. R. conorii, an organism that has been neglected in spite of its widespread distribution and pathogenic qualities, was studied in human subjects, animal models, and in vitro. The purpose of the work is to elucidate the pathology of boutonneuse fever and the pathogenic mechanisms which might be blocked therapeutically or prophylactically by examination for presence and severity of specific pathologic features. The study evaluated the following: cutaneous necrosis, vasculitis, thrombosis, and dermal edema. The predominant leukocytes were lymphocytes and macrophages: immunofluorescent Rickettsia conorii were demonstrated.


Descriptors :   *PATHOGENESIS , *BACTERIAL DISEASES , MODELS , IN VITRO ANALYSIS , ANIMALS , LYMPHOCYTES , LEUKOCYTES , VASCULAR DISEASES , NECROSIS , SKIN DISEASES , EDEMA , THROMBOSIS.


Subject Categories : MEDICINE AND MEDICAL RESEARCH
      MICROBIOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE