Accession Number : ADA094761


Title :   Korean Hemorrhagic Fever.


Descriptive Note : Final rept. 1 Jan-31 Dec 79,


Corporate Author : KOREA UNIV SEOUL COLL OF MEDICINE


Personal Author(s) : Lee,Ho Wang


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA094761


Report Date : Mar 1980


Pagination or Media Count : 49


Abstract : This report presents the results on (1) characterization of KHF virus and (2) transmission of the virus in animal reservoir host, employing the immunofluorescent technique. Physico-chemical properties of the virus are as follows: (a) The virus passed through 100 nm millipore filter buy not 50 nm filter. (b) RNA virus. (c) Deoxycholate, ether, chloroform, acetone, benzene and fluorocarbon inactived the virus. (d) U.V. light inactivated the virus. (e) The virus is lyophilizable. (f) Infectivity of virus is stable at ph 7.0 - 9.0 but inactivated completely at PH 5.0 (g) The virus was relatively stable at 4 deg C but inactivated readily at 37 deg C and (h) Ordinary disinfectants inactivated the virus. Virus transmission in the animal reservoir host are as follows: (a) Apodemus mice were infected by intranasal route. (b) The large amounts of virus was found in saliva and urine but small amounts in feces. (c) Horizontal transmission of the virus among Apodemus occurred beginning 10 days after inoculation of the source cohort, and further groups of animals became infected when caged with Apodemus infected up to 38 days previously. Results were not different when ectoparasitized and clean animals were used in the experiment. (d) Attempts to demonstrate the virus in suspensions of ectoparasites harvested from infected Apodemus were failed.


Descriptors :   *HEMORRHAGIC FEVERS , IDENTIFICATION , DIAGNOSIS(MEDICINE) , KOREA , MICE , IMMUNOASSAY , SEROLOGY , INFECTIOUS DISEASE TRANSMISSION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE