Accession Number : ADA082685


Title :   Mammalian Toxicological Evaluation of DIMP and DCPD. Phase 2


Descriptive Note : Final rept. on Phase 2,


Corporate Author : LITTON BIONETICS INC KENSINGTON MD


Personal Author(s) : Hart, E R


Full Text : http://www.dtic.mil/dtic/tr/fulltext/u2/a082685.pdf


Report Date : Mar 1980


Pagination or Media Count : 531


Abstract : Specially purified samples of DIMP proved non-mutagenic. About 90% of administered DIMP is recoverable from the urine of rats, mice or dogs and 95% of this is in the form of isopropyl-methyl-phosphonic acid (IMPA). No teratologic effects were produced by dietary levels of 100 to 3000 ppm given on days 6 through 15 of gestation. Dietary incorporation of DIMP at levels of 300 and 3000 ppm produced no dose-related reproductive response in the rat over three successive generations with two matings per generation. Nerve fiber degeneration (demyelination) in chickens treated once at 1500 mg/kg or twice at 1000 or 500 mg/kg. No toxic effects were seen over a 90-day period in beagles given dietary mixes containing 150, 1500 or 3000 ppm or DIMP. Purified DCPD proved non- mutagenic. No teratologic effects were observed in rats given dietary levels of 80, 250 or 750 ppm on days 6 through 15 of gestation. No deleterious effects on reproductive processes were seen with two matings per generation. No important evidence of toxicity was seen in beagles given 100, 300 or 1000 ppm in their diet over a 90 day period.


Descriptors :   *TOXICITY , MAMMALS , METABOLISM , PHARMACOKINETICS , CHICKENS , DOGS , MICROBIOLOGICAL TESTS , BIOASSAY , DIET , MUTAGENS , TABLES(DATA) , RATS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE