Accession Number : ADA060051


Title :   World Reference Center for Arboviruses.


Descriptive Note : Annual rept. 1 Jul 76-30 Jun 77,


Corporate Author : YALE UNIV NEW HAVEN CONN DEPT OF EPIDEMIOLOGY AND PUBLIC HEALTH


Personal Author(s) : Shope,Robert E


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA060051


Report Date : Aug 1977


Pagination or Media Count : 109


Abstract : The identification of Rift Valley fever virus from Egypt and bluetongue virus from Australia had worldwide impact. Eighty-four other viruses were identified, many new to science or new to the geographic site of isolation. Techniques were developed to study arbovirus attachment to neural and non-neural cells, to demonstrate high salt HA with dengue virus, to show HA in mosquito tissues with WEE virus, and to determine pathogenicity and serologic reactions to bunyavirus RNA-reassortants. Broadly based surveys of arbovirus antibody in man were done with sera from Brazil, Guam, USA, Colombia, and the New Guinea region. SLE antibody was detected in western Connecticut animals. Arboviruses were not implicated serologically in Parkinson's disease, amyotrophic lateral sclerosis, or multiple sclerosis. Lyme disease was associated in distribution with Ixodes ticks but the etiologic agent was not isolated. The reference center distributed 566 ampoules of reference sera, viruses, and antigens during 1977; mosquito and vertebrate cell lines were also distributed. (Author)


Descriptors :   *ARBOVIRUSES , IDENTIFICATION , DIAGNOSIS(MEDICINE) , SURVEYS , AUSTRALIA , SEROLOGY , VENEZUELA , CAMBODIA , TANZANIA


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE