Accession Number : ADA047067


Title :   Mammalian Toxicity of Munition Compounds. Phase II. Effects of Multiple Doses. Part I. Trinitroglycerin


Descriptive Note : Progress rept no. 2, 1 Mar 75-25 Feb 76


Corporate Author : MIDWEST RESEARCH INST KANSAS CITY MO


Personal Author(s) : Lee, Cheng-Chun ; Ellis, Harry V., III ; Kowalski, John J. ; Hodgson, John R. ; Hwang, Shang W.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA047067


Report Date : 25 FEB 1976


Pagination or Media Count : 187


Abstract : The effects of oral doses of trinitroglycerin (TNG) after administration for up to 13 weeks, were investigated in dogs, rats and mice. A detailed study on the disposition and metabolism was performed in rats and the metabolic pathways, compared in dogs, mice, rabbits, monkeys and human cadaver liver. No adverse effects were seen in dogs given 1 mg/kg/day TNG for 4 weeks followed by 5 mg/kg/day for an additional 9 weeks. Larger doses (25 to 200 mg/ kg/day for 5 days) produced methemoglobinemia, peaking about 4 hr after dosing, with the peak height and duration dose-related. Rats eating 1,400 mg/kg/day of TNG showed toxic effects: decreased feed consumption, weight loss, rough coat, testicular atrophy and degeneration and hemosiderosis. Some recovery occurred despite continued dosing, before the 13th week. Mice fed 11 or 100 mg/kg/day for 3 weeks followed by 60 or 580 mg/kg/day for 10 weeks had some extramedullary hematopoiesis, but no other effects. Mice absorbed 50 to 70% of an oral dose of TNG within 24 hr; the other species, 72 to 95%. Most body tissues picked up the C-14 radiolabel. Rats and mice excreted C-14 compounds in air and urine, the other species primarily in urine.


Descriptors :   *TOXICITY , *EXPLOSIVES , *IMMUNOLOGY , *NITROGLYCERIN , MAMMALS , RATS , METABOLISM , HUMAN BODY , MICE , LIVER , DOGS , LABELED SUBSTANCES , RABBITS , MONKEYS , HEMATOLOGY , BLOOD CHEMISTRY.


Subject Categories : TOXICOLOGY
      AMMUNITION AND EXPLOSIVES


Distribution Statement : APPROVED FOR PUBLIC RELEASE