Accession Number : ADA034976


Title :   A Deficiency of Hematopoietic Stem Cells in Steel Mice.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : McCarthy,K F ; Ledney,G D ; Mitchell,R G


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA034976


Report Date : Sep 1976


Pagination or Media Count : 14


Abstract : Steel-Dickie mice which have a genetic defect were selected for a model to determine some of the interaction of ionizing radiation with bone marrow cells. Therefore, population sizes of high self-renewal potential stem cells, i.e., colony forming units and low self-renewal potential stem cells, i.e., transient endogenous colony forming units in Steel mice and their normal congenic littermates were measured and compared. By correcting for differences in the seeding efficiency 'f', it was possible to demonstrate that Sl Sl(d) mice suffer a deficiency of both stem cell populations. It is concluded that the defective stromal tissue of the Sl(d) mouse does not support normal size stem cell populations.


Descriptors :   *BONE MARROW, *RADIATION EFFECTS, MORPHOLOGY, TRANSITIONS, IRRADIATION, MICE, GENETICS, COLONIES(BIOLOGY), SPLEEN


Subject Categories : Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE