Accession Number : ADA033511


Title :   Suppression by 1,3-Butanediol of the Ethanol Withdrawal Syndrome in Rats.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Majchrowicz,E ; Hunt,W A ; Piantadosi,C


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA033511


Report Date : Jul 1976


Pagination or Media Count : 14


Abstract : 1-3-Butanediol (BD) was tested for its ability to suppress an ethanol withdrawal syndrome. Male Sprague-Dawley rats were rendered physically dependent upon ethanol by intragastric administration of 9-15 g/kg of ethanol per day over a 4-day period. A nonintoxicating dose of BD of 4 g/kg, p.o., administered after elimination of ethanol from the blood was effective against the tremulous and convulsive components in all animals for 1-5 hours. This period of time coincided with the time of maximum severity of the withdrawal syndrome as seen in the control animals. These results suggest that BD may be useful in the treatment of the ethanol withdrawal syndrome in man. (Author)


Descriptors :   *SIGNS AND SYMPTOMS, *ETHANOLS, *DRUG WITHDRAWAL, RATS, CLINICAL MEDICINE, DOSAGE, THERAPY, SUPPRESSION, BLOOD CIRCULATION, CONVULSIVE DISORDERS, INTOXICATION, BUTANOLS, INGESTION(PHYSIOLOGY)


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE