Accession Number : ADA033509


Title :   Skeletal Uptake of (99m) Tc Diphosphonate in Relation to Local Bone Blood Flow.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Siegel,B. A. ; Donovan,R. L. ; Alderson,P. O. ; Mack,G. R.


Report Date : JUL 1976


Pagination or Media Count : 13


Abstract : The right-left (R-L) ratios for tibial uptake of Tc99 diphosphonate (EHDP) and relative blood flow (from microsphere distribution) were determined in control rats and rats with right femoral artery ligation or healing right tibial fractures. There was highly significant correlation (r = 0.917; P less than 0.0001) between the TC99 EHDP uptake and relative blood flow for relative flow ratios less than 1.7. When relative tibial blood flow was greater than 1.7, there was little further increase in Tc99 EHDP uptake. In addition, femoral artery ligation in rats with healing fractures resulted in a more marked reduction of flow than of Tc99 EHDP uptake. Our results suggest that regional bone flow is a major determinant of Tc99 EHDP uptake, but changes in regional tracer extraction efficiency are also important. This work increases our understanding of the basic mechanisms of Tc99 phosphate bone imaging. The results can be applied toward improved clinical interpretations, and benefit patients(soldiers) with trauma, bone grafts, osteomyelitis or other conditions which can be detected with these techniques. (Author)


Descriptors :   *IN VIVO ANALYSIS, *PHOSPHONATES, *TECHNETIUM COMPOUNDS, *TIBIA, RATS, CLINICAL MEDICINE, RADIOACTIVE ISOTOPES, BLOOD CIRCULATION, BONES, TRAUMATIC SHOCK, FEMORAL ARTERIES, BONE FRACTURES, LIGATURES.


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH
      RADIATION AND NUCLEAR CHEMISTRY


Distribution Statement : APPROVED FOR PUBLIC RELEASE