Accession Number : ADA033406


Title :   Cerebellar cGMP Levels Reduced by Narcotic and Hypnotic Drugs: Correlation with Drug-Induced Ataxia.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Katz,J. B. ; Catravas,G. N.


Report Date : JUN 1976


Pagination or Media Count : 12


Abstract : Maintenance of normal coordination and smooth motor activity requires an intact Purkinje cell system in the cerebellum. Acute adminstration of morphine or pentobarbital results in a reduction in the cGMP pool of cerebellar Purkinje cells that is both dose and time dependent. The induction of ataxia by these drugs correlates with their ability to depress cerebellar cGMP levles. Animals tolerant to morphine show neither the cGMP reduction nor ataxia.


Descriptors :   *ATAXIA, *MORPHINE, *PENTOBARBITAL, RATS, TIME, SHORT RANGE(TIME), DOSAGE, CYCLIC COMPOUNDS, MOTOR NEURONS, DRUG TOLERANCE, CEREBELLUM.


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE