Accession Number : ADA033404


Title :   Effect of Chronic Administration of Morphine on the Activity of Brain Monoamine Oxidase in the Rat.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Catravas,G. N. ; Takenaga,J. ; McHale,C. G.


Report Date : JUN 1976


Pagination or Media Count : 14


Abstract : The effect of chronic administration of morphine on the activity of monoamine oxidase in specific regions of the brain of rats has been investigated. It was found that, shortly after the last administration of morphine, brain monoamine oxidase was drastically reduced in rats which had been chronically treated with morphine and which had exhibited a hyperactivity syndrome manifested by compulsive gnawing and spasmodic jumping. Lowest values were seen at approximately 30 minutes and returned to nearly normal levels by 6 hours after the last injection. In contrast, no significant changes were observed in the activity of this enzyme in animals that did not exhibit this syndrome after morphine adminstration. The study of morphine-induced changes in brain monoamine oxidase described above provides information on basic mechanisms of function of the mammalian central nervous system. This information is of great value to studies of effects of other toxic agents including ionizing and nonionizing radiation. (Author)


Descriptors :   *BRAIN, *RATS, *TOXICITY, *MONOAMINE OXIDASE, *MORPHINE, ENZYMES, CENTRAL NERVOUS SYSTEM, TOLERANCES(PHYSIOLOGY).


Subject Categories : BIOCHEMISRTY
      TOXICOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE