Accession Number : ADA033403


Title :   Ethanol-Induced Depletion of Cerebellar Guanosine 3',5'-Cyclic Monophosphate Levels.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Redos,J. D. ; Catravas,G. N. ; Hunt,W. A.


Report Date : JUN 1976


Pagination or Media Count : 11


Abstract : Single doses of ethanol induce a severe depletion (95 percent) of cerebellar guanosine 3-5-cyclic monophosphate (C-GMP) levels within 1 hour after administration. The degree of this depletion is a function of the amount of ethanol in the blood. Interactions between ethanol and C-GMP may account for some of the intoxicating properties of ethanol. The results of this study provide further information on the development and exploration of models for chronic insults to the brain, such as long-term exposure to toxic chemicals and ionizing and nonionizing radiation. (Author)


Descriptors :   *BRAIN, *PHOSPHATES, *ETHANOLS, DEPLETION, RATS, CLINICAL MEDICINE, DOSAGE, LEVEL(QUANTITY), THERAPY, EXPOSURE(PHYSIOLOGY), IN VIVO ANALYSIS, IONIZING RADIATION, BLOOD CIRCULATION, INTOXICATION.


Subject Categories : BIOCHEMISRTY
      MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE