Accession Number : ADA033232


Title :   Localization of 99m sub T c Diphosphonate in Acutely Injured Muscle: Relationship to Muscle Calcium Deposition.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Siegel,B A ; Engel,W K ; Derrer,E C


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA033232


Report Date : Aug 1976


Pagination or Media Count : 28


Abstract : In rats with experimental ischemic myopathy there was a significant correlation (r=0.778, p0.001) between muscle uptake of TC(99m) diphosphonate (EHDP) and tissue calcium concentration. In addition, the accumulation of both calcium and Tc(99m) EHDP in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Results suggest that the uptake of 99mTc EHDP in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.


Descriptors :   *CALCIUM, *MUSCLES, *RADIOPHARMACEUTICALS, POTASSIUM, HISTOLOGY, TRACER STUDIES, BIOLOGICAL STAINS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE