Accession Number : ADA033232
Title : Localization of 99m sub T c Diphosphonate in Acutely Injured Muscle: Relationship to Muscle Calcium Deposition.
Descriptive Note : Scientific rept.,
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Siegel,B A ; Engel,W K ; Derrer,E C
Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD= ADA033232
Report Date : Aug 1976
Pagination or Media Count : 28
Abstract : In rats with experimental ischemic myopathy there was a significant correlation (r=0.778, p0.001) between muscle uptake of TC(99m) diphosphonate (EHDP) and tissue calcium concentration. In addition, the accumulation of both calcium and Tc(99m) EHDP in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Results suggest that the uptake of 99mTc EHDP in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.
Descriptors : *CALCIUM , *MUSCLES , *RADIOPHARMACEUTICALS , POTASSIUM , HISTOLOGY , TRACER STUDIES , BIOLOGICAL STAINS
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE