Accession Number : ADA029228


Title :   Immunity in Chagas' Disease.


Descriptive Note : Final rept. Sep 73-May 76,


Corporate Author : GORGAS MEMORIAL LAB BALBOA HEIGHTS CANAL ZONE


Personal Author(s) : Wood,Duell E


Report Date : 25 Aug 1976


Pagination or Media Count : 16


Abstract : This is the final report on the immunity in Chagas' disease contract and it summarizes the results of a diversity of studies directed toward understanding the immunology of this dreaded affliction. Among the achievements mentioned are the development of a culture system which provides infective form Trypanosoma cruzi for immunology studies and the use of these infective forms in the development of a sensitive specific, indirect immunofluorescent antibody test for Chagas' disease. Also mentioned are the facts that the cell membranes of live trypomastigotes are not immunoreactive with the humoral immune response of an infected host and that suppression of parasitemias in chronic Chagas' disease is probably a function of the cell immune system of the host. (Author)


Descriptors :   *TRYPANOSOMA CRUZI , TEST METHODS , DIAGNOSIS(GENERAL) , IMMUNITY , IMMUNIZATION , CULTURES(BIOLOGY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE