Accession Number : ADA026841
Title : Effects of Chronic Inhalation of Propylene Glycol 1,2-Dinitrate on the Conditioned Avoidance behavior of Primates
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Young, R W ; Curran, C R ; Franz, C G ; Jenkins, Jr, L J
Report Date : Jun 1976
Pagination or Media Count : 19
Abstract : Four primates (Macaca mulatta) were trained to stable levels of performance on a multiple avoidance schedule of reinforcement. The schedule included alternating sessions of discrete trial cued avoidance and free operant avoidance, separated by 3-minute rest periods. Two of the animals were exposed to successive atmospheric concentrations of propylene glycol 1,2-dinitrate (PGDN) vapors of 1.8, 5.6, 11.0, and 28.2 mg/cu. m. Exposure occurred on a 23- hour per day basis in a Rochester-type inhalation chamber at the Navy Toxicology Unit. Consecutive exposures lasted 35, 56, 20 and 14 days respectively. The other two animals were housed in an identical inhalation chamber but remained in a normal atmosphere for the duration of the testing period. These animals served as controls. Plasma concentrations of PGDN appeared to increase each time the chamber concentration was increased, however none of the four PGDN concentrations had a discernible effect on avoidance behavior. There was no measurable change in the overall behavior of either test animal which could have been attributed to general debilitation, sensory deficit, or motor dysfunction.
Descriptors : *PROPELLANTS , *NITRATES , *TOXICITY , CONDITIONING(LEARNING) , PSYCHOLOGICAL TESTS , AVOIDANCE , RHESUS MONKEYS , INHALATION , PROPENES , LONG RANGE(TIME) , ALIPHATIC COMPOUNDS , BEHAVIOR
Subject Categories : Toxicology
Ammunition and Explosives
Distribution Statement : APPROVED FOR PUBLIC RELEASE