Accession Number : ADA024095


Title :   Iodinated Bleomycin: An Unsatisfactory Radiopharmaceutical for Tumor Localization.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Eckelman,W. C. ; Kubota,H. ; Siegel,B. A. ; Komai,T. ; Rzeszotarski,W. J.


Report Date : MAR 1976


Pagination or Media Count : 14


Abstract : Cobalt-57 bleomycin is a clinically useful tumor localizing agent, but attempts to label bleomycin (BLEO) with other radionuclides have been made because of the long physical half-life of Co(57). As an alternative labeling approach, BLEO was iodinated both directly on the imidazole ring and indirectly by reaction with N-succinimidyl 3-(4-hydroxy, 3-iodophenyl) propionate. Directly iodinated BLEO retained antibacterial activity, but in tumor-bearing rats showed a lower tumor to blood ratio at 2 hours (2.3) than was obtained with Co(57) BLEO (11.8). The antibacterial activity of the indirectly labeled BLEO was markedly reduced and this material showed a tumor to blood ratio at 2 hours of 0.55.


Descriptors :   *NEOPLASMS, *RADIOACTIVE ISOTOPES, *ANTIBIOTICS, *RADIOPHARMACEUTICALS, *IODINE COMPOUNDS, RATS, COMPARISON, DIAGNOSIS(MEDICINE), SUBSTITUTES, LABELED SUBSTANCES, COBALT, IODINATION.


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE