Accession Number : ADA024095
Title : Iodinated Bleomycin: An Unsatisfactory Radiopharmaceutical for Tumor Localization.
Descriptive Note : Scientific rept.,
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Eckelman,W C ; Kubota,H ; Siegel,B A ; Komai,T ; Rzeszotarski,W J
Report Date : Mar 1976
Pagination or Media Count : 14
Abstract : Cobalt-57 bleomycin is a clinically useful tumor localizing agent, but attempts to label bleomycin (BLEO) with other radionuclides have been made because of the long physical half-life of Co(57). As an alternative labeling approach, BLEO was iodinated both directly on the imidazole ring and indirectly by reaction with N-succinimidyl 3-(4-hydroxy, 3-iodophenyl) propionate. Directly iodinated BLEO retained antibacterial activity, but in tumor-bearing rats showed a lower tumor to blood ratio at 2 hours (2.3) than was obtained with Co(57) BLEO (11.8). The antibacterial activity of the indirectly labeled BLEO was markedly reduced and this material showed a tumor to blood ratio at 2 hours of 0.55.
Descriptors : *NEOPLASMS , *RADIOACTIVE ISOTOPES , *ANTIBIOTICS , *RADIOPHARMACEUTICALS , *IODINE COMPOUNDS , RATS , COMPARISON , DIAGNOSIS(MEDICINE) , SUBSTITUTES , LABELED SUBSTANCES , COBALT , IODINATION
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE