Accession Number : ADA024093


Title :   The Effect of a Simulated Subarachnoid Hemorrhage on Cerebral Blood Flow in The Monkey.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Martins,A. N. ; Doyle,T. F. ; Newby,N. ; Kobrine,A. I. ; Ramirez,A.


Report Date : MAR 1976


Pagination or Media Count : 27


Abstract : The hydrogen clearance method was used to measure local and total cerebral blood flow (CBF) in the rhesus monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). CBF remained stable after SAH unless SAH was associated with a fall in cerebral perfusion pressure. In addition, cerebrovascular resistance did not increase after SAH. These results suggest that vasoactive agents in fresh whole blood, and the arterial spasm they produce when added to cerebrospinal fluid, play only a limited role in the pathogenesis of ischemic encephalopathy that follows an SAH. (Author)


Descriptors :   *BLOOD CIRCULATION, *CEREBRAL CORTEX, SIMULATION, MODELS, RHESUS MONKEYS, RESISTANCE(BIOLOGY), BLOOD PRESSURE, HEMORRHAGE, CARDIOVASCULAR AGENTS, CEREBROVASCULAR SYSTEM.


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE