Accession Number : ADA024090


Title :   Hyperemia and Edema in the Monkey Spinal Cord Following Injury: Modified by Histamine Antagonists.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Doyle,T. F. ; Kobrine,A. I. ; Martins,A. N.


Report Date : MAR 1976


Pagination or Media Count : 15


Abstract : Using the hydrogen washout technique, blood flow in the lateral funiculus of the spinal cord of rhesus monkeys was measured before and after a contusion sufficient to render the animals paraplegic. In untreated animals, the blood flow increased 1 hour after injury to almost twice the normal flow rate (17.6 to 31.8 ml/min per 100 g). When the animals were pretreated with histamine antagonists (chlorpheniramine, an H sub 1 antagonist, and metiamide, an H sub 2 antagonist), there was no significant increase in blood flow following contusion. Antihistamines were ineffective in preventing edema. (Author)


Descriptors :   *WOUNDS AND INJURIES, *BLOOD CIRCULATION, *SPINAL CORD, *HISTAMINE, RHESUS MONKEYS, HOMEOSTASIS, ANTIHISTAMINICS, EDEMA.


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE