Accession Number : ADA024090


Title :   Hyperemia and Edema in the Monkey Spinal Cord Following Injury: Modified by Histamine Antagonists.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Doyle,T F ; Kobrine,A I ; Martins,A N


Report Date : Mar 1976


Pagination or Media Count : 15


Abstract : Using the hydrogen washout technique, blood flow in the lateral funiculus of the spinal cord of rhesus monkeys was measured before and after a contusion sufficient to render the animals paraplegic. In untreated animals, the blood flow increased 1 hour after injury to almost twice the normal flow rate (17.6 to 31.8 ml/min per 100 g). When the animals were pretreated with histamine antagonists (chlorpheniramine, an H sub 1 antagonist, and metiamide, an H sub 2 antagonist), there was no significant increase in blood flow following contusion. Antihistamines were ineffective in preventing edema. (Author)


Descriptors :   *WOUNDS AND INJURIES , *BLOOD CIRCULATION , *SPINAL CORD , *HISTAMINE , RHESUS MONKEYS , HOMEOSTASIS , ANTIHISTAMINICS , EDEMA


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE