Accession Number : ADA022072


Title :   Dopamine Depolarizing Response in a Vertebrate Neuronal Somatic Cell Hybrid.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Myers,P. R. ; Livengood,D. R.


Report Date : DEC 1975


Pagination or Media Count : 14


Abstract : The response to iontophoretically applied dopamine was studied in the somatic cell hybrid 108CC15. Dopamine gave a depolarizing response with a conductance increase. The reversal potential for the response was -15.9 mV. Known dopamine antagonists blocked the response. These results demonstrate a dopamine response in a single cell preparation of vertebrate neuronal origin and the utilization of cultured cells to study receptor mechanisms in an isolated, controlled environment. (Author)


Descriptors :   *DOPAMINE, *NERVE TRANSMISSION, DEPOLARIZATION, HYBRID SYSTEMS, NERVE CELLS, RESPONSE(BIOLOGY), CELLS(BIOLOGY), CULTURES(BIOLOGY), CHEMORECEPTORS.


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE