Accession Number : ADA021766


Title :   Technetium-99m Diphosphonate Uptake in Skeletal Muscle: A Quantitative Index of Acute Damage.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Siegel,B. A. ; Engel,W. K. ; Derrer,E. C.


Report Date : DEC 1975


Pagination or Media Count : 15


Abstract : In rats with ischemic myopathy induced by aortic ligation and 5-hydroxytryptamine, there was good correlation of the skeletal muscle concentration of 99mTC diphosphonate with the increase of plasma creatine phosphokinase and the decrease in muscle potassium. This radionuclide tracer method can be used to quantitate acute injury in individual muscles and provides a basis for clinical nuclear imaging in patients with a variety of disorders involving muscle fiber damage. (Author)


Descriptors :   *MUSCLES, *RADIOACTIVE ISOTOPES, RATS, ENZYMES, QUANTIZATION, WOUNDS AND INJURIES, MALES, POTASSIUM, NECROSIS, TRACER STUDIES, MUSCULOSKELETAL DISEASES, NUCLEAR MEDICINE.


Subject Categories : RADIOBIOLOGY
      RADIATION AND NUCLEAR CHEMISTRY


Distribution Statement : APPROVED FOR PUBLIC RELEASE