Accession Number : ADA020976


Title :   An Experimental Model for Chronic Communicating Hydrocephalus,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Flor,W. J. ; James,A. E. , Jr. ; Strecker,E. P. ; Rish,B. L.


Report Date : NOV 1975


Pagination or Media Count : 23


Abstract : A simple, relatively atraumatic and reliable technique is described for producing experimental chronic communicating hydrocephalus in dogs, cats, and primates by the subarachnoid injection of a room temperature curing silicone rubber in the anterior basal cisterns. Development of hydrocephalus is monitored by cisternography and by studies of radiopharmaceutical transfer from cerebrospinal fluid to blood. This model parallels closely the circumstances observed in the human disease. Its chronic time frame (1 to 10 months) allows meaningful examination of pathophysiological and neuroanatomical changes responsible for the observed human clinical signs.


Descriptors :   *NERVOUS SYSTEM DISEASES, BRAIN, MODELS, PATHOGENESIS, CENTRAL NERVOUS SYSTEM, DOGS, RHESUS MONKEYS, CATS, CEREBROSPINAL FLUID, SILICONE PLASTICS.


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE