Accession Number : ADA020381


Title :   Dopamine Uptake in the Somatic Cell Hybrid NX31.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Myers,P. R. ; Shain,W. G. , Jr


Report Date : AUG 1975


Pagination or Media Count : 32


Abstract : The authors have investigated the kinetics and pharmacology of membrane transport of 3,4-dihydroxyphenylethylamine (dopamine) in the neuroblastoma clone N18TG2 and mouse sympathetic ganglion cells. NX31 was grown in exponential growth phase and in the presence of dibutyryl cyclic adenosine monophosphate, a compound known to initiate morphological and biochemical modulation, in order to investigate possible transitions in kinetic properties during differentiation.


Descriptors :   *NEUROCHEMISTRY, *CATECHOLAMINES, *DOPAMINE, TISSUE CULTURE CELLS, METABOLISM, IN VITRO ANALYSIS, TRANSPORT PROPERTIES, PHARMACOLOGY, BIOLOGICAL ABSORPTION, NUCLEOTIDES, NEUROCHEMICAL TRANSMISSION.


Subject Categories : BIOCHEMISRTY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE