Accession Number : ADA020381


Title :   Dopamine Uptake in the Somatic Cell Hybrid NX31


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Myers, P R ; Shain, Jr, W G


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA020381


Report Date : Aug 1975


Pagination or Media Count : 32


Abstract : The authors have investigated the kinetics and pharmacology of membrane transport of 3,4-dihydroxyphenylethylamine (dopamine) in the neuroblastoma clone N18TG2 and mouse sympathetic ganglion cells. NX31 was grown in exponential growth phase and in the presence of dibutyryl cyclic adenosine monophosphate, a compound known to initiate morphological and biochemical modulation, in order to investigate possible transitions in kinetic properties during differentiation.


Descriptors :   *CATECHOLAMINES, *DOPAMINE, *NEUROCHEMISTRY, BIOLOGICAL ABSORPTION, IN VITRO ANALYSIS, METABOLISM, NEUROCHEMICAL TRANSMISSION, NUCLEOTIDES, PHARMACOLOGY, TISSUE CULTURE CELLS, TRANSPORT PROPERTIES


Subject Categories : Biochemistry
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE