Accession Number : ADA016801


Title :   Radiation-Released Histamine in the Rhesus Monkey as Modified by Mast Cell Depletion and Antihistamine


Descriptive Note : Scientific rept.


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Doyle, T. F. ; Strike, T. A.


Full Text : http://www.dtic.mil/get-tr-doc/pdf?AD=ADA016801


Report Date : JUN 1975


Pagination or Media Count : 16


Abstract : Changes in blood histamine concentrations of rhesus monkeys were measured after a 4000-rad dose of mixed gamma-neutron radiation. All animals were pretreated with amino-guanidine to retard histamine catabolism. Histamine concentrations increased from 26 + or - 13.5 to 235 + or - 16 ng/ml after irradiation. When the animals were pretreated with an antihistamine, chlorpheniramine (3 mg/kg), histamine concentrations changed from 25.7 + or - 13.5 to 462 + or - 226 ng/ml after irradiation. When the monkeys were pretreated with a specific mast cell histamine depleter, compound 48/80 (1mg/kg per day) for four consecutive days and then irradiated (4000 rads), histamine concentrations did not change significantly. When 48/80 was given 20 min after irradiation, histamine concentrations changed from 18 + or - 2 ng/ml to a maximum of 35 + or - 9 ng/ml after 48/80 injection. (Author)


Descriptors :   *RADIOBIOLOGY, *HISTAMINE, MAST CELLS, RESPONSE(BIOLOGY), CONCENTRATION(CHEMISTRY), RADIATION DOSAGE, RHESUS MONKEYS, BLOOD PRESSURE, CATABOLISM, NEUTRON IRRADIATION, ANTIHISTAMINICS, BLOOD CHEMISTRY, HYPOTENSION, DEPLETION, GAMMA RAYS


Subject Categories : RADIOBIOLOGY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE