Accession Number : ADA016800


Title :   Histamine-Induced Hypotension Modified by H1 and H2 Antagonists.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Doyle,T. F. ; Strike,T. A.


Report Date : JUN 1975


Pagination or Media Count : 16


Abstract : The hypotensive response of monkeys to exogenous histamine was measured when the histamine was given without antagonist, after chlorpheniramine (10 mg/kg) or mepyramine (10 mg/kg), and after these two antagonists in combination with burimamide (20 mg/kg). The dose of histamine needed to elicit a 50 percent maximal response was: without antagonist, 0.115 micrograms/kg; after chlorpheniramine, 13.5 micrograms/kg; after chlorpheniramine and burimamide, 23.5 micrograms/kg; after mepyramine, 23.0 micrograms/kg; and after mepyramine and burimamide, 55.0 micrograms/kg.


Descriptors :   *ANTIHISTAMINICS, *HYPOTENSION, DOSAGE, RESPONSE(BIOLOGY), RHESUS MONKEYS, BLOOD PRESSURE, HISTAMINE, CHEMORECEPTORS.


Subject Categories : ANATOMY AND PHYSIOLOGY
      PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE