Accession Number : ADA011046


Title :   Radionuclide Bone Imaging in the Evaluation of Osseous Allograft Systems.


Descriptive Note : Scientific rept.,


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Kelly,J. F. ; Cagle,J. D. ; Stevenson,J. S. ; Adler,G. J.


Report Date : FEB 1975


Pagination or Media Count : 26


Abstract : Evaluation of the progress of osteogenic activity in mandibular bone grafts in dogs by a noninvasive, nondestructive radionuclide method is feasible. The method provides a meaningful sequential interpretation of osseous repair more sensitive than conventional radiography. It is presumed that accumulating hydroxyapatite is being labelled by the imaging agent technetium diphosphonate. The osseous allograft systems studied were comparable to or exceeded autografts in their repair activity in mandibular discontinuity defects as judged by radionuclide imaging. A lyophilized mandibular allograft segment augmented with autologous cancellous marrow was more active than autograft controls at 3 and 6 weeks and was the most active system studied. Allograft segments augmented with lyophilized crushed cortical allogeneic bone particles were equal to controls at 3 weeks and more active than controls at 6 weeks. Lyophilized crushed cortical allogeneic bone particles retained in a Millipore filter while not clinically stable at 6 weeks did show osteogenic activity equal to control autografts at this interval.


Descriptors :   *IMAGES, *LABELED SUBSTANCES, *BONES, *SURGICAL TRANSPLANTATION, SCANNING, EXPERIMENTAL DATA, DOGS, RADIOACTIVE ISOTOPES, HEALING, LYOPHILIZATION, MANDIBLE, TECHNETIUM.


Subject Categories : MEDICINE AND MEDICAL RESEARCH


Distribution Statement : APPROVED FOR PUBLIC RELEASE